GROUP SEQUENTIAL DESIGN FOR TIME-TO-EVENT OUTCOME WITH NON-PROPORTIONAL HAZARDS USING THE CONCEPT OF RELATIVE TIME UTILIZING TWO DIFFERENT WEIBULL DISTRIBUTIONS

A group sequential design allows investigators to sequentially monitor efficacy and safety as part of interim testing in phase III trials.Literature is well developed in the case of continuous and binary outcomes, however, in case of trials with a time-to-event outcome, popular methods of sample size calculation often assume proportional hazards.In

Gram-negative bacteria protect themselves with an outermost layer containing lipopolysaccharide (LPS).O-antigen-specific bacteriophages use tailspike proteins (TSP) Transmission to recognize and cleave the O-polysaccharide part of LPS.However, O-antigen composition and structure can be highly variable depending on the environmental conditions.It is

The number of different languages in Europe by far exceeds the number of countries.All European countries have national languages, and in nearly all of them there are minority languages as well, whereas all major languages have dialects.National borders rarely coincide with linguistic borders, but the latter (including dialect borders) mark by thei